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Concurrent Poststreptococcal Acute Glomerulonephritis and Schonlein‐Henoch Purpura
Author(s) -
Onisawa Shin,
Morishima Naoya,
Lchimura Tohju
Publication year - 1989
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1989.tb01338.x
Subject(s) - medicine , henoch schonlein purpura , purpura (gastropod) , glomerulonephritis , dermatology , immunology , vasculitis , pathology , kidney , ecology , disease , biology
A 5‐year‐old Japanese boy developed concurrent poststreptococcal acute glomerulonephritk (PSAGN) and Schonlein‐Henoch purpura (SHP). An elevated titer of ASK on admission confiied the preceding streptococcal infection. Arthritis of the left knee and petechiae on admission were regarded as features of SHP. The presence of SHP was further confiied by the pathological fmding of leukocytoclastic vasculitk in the skin. PSACN was strongly suspected due to the sndings of microscopic hematuria and hypocomplementemia in the acute phase. The concwrence of SHP and PSAGN suggests similar underlying pathophys iological processes as poststreptococcal sequelae. At the height of the illness, peripheral blood lymphocyte subset analysis showed a marked increase in the suppressor inducer T subset and a reciprocal decrease in the helper T subset. lhis alteration in T lymphocyte subsets was regarded as indicative of the immunological derangement in this patient.