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Very Long‐Chain Fatty Acids in Erythrocyte Membrane Phospholipids in Adrenoleukodystrophy
Author(s) -
Tanaka Kazuhiko,
Shimada Morimi,
Naruto Toshiyuki,
Yamamoto Hisashi,
Nishizawa Kashirou,
Saeki Yukikazu
Publication year - 1989
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1989.tb01279.x
Subject(s) - adrenoleukodystrophy , phosphatidylethanolamine , sphingomyelin , phosphatidylcholine , membrane , medicine , fatty acid , chromatography , biochemistry , phospholipid , peroxisome , chemistry , receptor
Mass fragmentography was used to analyze the very longchain fatty acid (VLCFA) composition of erythrocyte membrane phospholipids. The VLCFA content decreased in the order sphingomyelin (SM), phosphatidylcholine (PC) and phosphatidylethanolamine (PE). The tetracosanoic acid (C24:0) and hexacosanoic acid (C26:0) content of both SM and PC in patients with adrenoleukodystrophy (ALD) were significantly higher than those in controls. The VLCFA content of PE was too small, in comparison with those of SM, to be accurately determined. ( Acta Paediatr Jpn 1989;31: 136–143)