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Serum Anti‐PT and Anti‐FHA Antibody Levels, and Agglutinin Titers after Administration of Accellular Pertussis Vaccines
Author(s) -
KunoSakai Harumi,
Kimura Mikio,
Sato Yuji,
Tsunoda Akira,
Urano Takashi,
Isomura Shin,
Kamiya Hitoshi
Publication year - 1989
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1989.tb01277.x
Subject(s) - medicine , filamentous haemagglutinin adhesin , pertussis toxin , whooping cough , diphtheria , agglutinin , titer , antibody , pertussis vaccine , vaccination , antibody titer , immunology , bordetella pertussis , virology , immunization , g protein , receptor , lectin , genetics , biology , bacteria
Simultaneous evaluation of acellular pertussis vaccines from three manufacturers (Takeda, Biken, and Chiba) was performed. After receiving two doses of acellular pertussis vaccine in the form of DPT (diphtheria pertussis tetanus), both infants and children showed high serum anti‐PT (pertussis toxin) and anti‐FHA (fdamentous hemagglutinin) antibody levels. These levels were equivalent to those observed in children in the convalescent stage of natural pertussis infection. Children who received 2 doses of Biken vaccine showed higher anti‐PT and anti‐FHA antibody levels than those who received Takeda or Chiba vaccine. Elevation of agglutinin titers was observed in children who received either Takeda or Chiba vaccine. ( Acta Paediatr Jpn 1989; 31: 120–126)