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Modulation of Immunological Abnormalities of Growth Hormone‐Deficient Children by Growth Hormone Treatment
Author(s) -
Matsuura Mikio,
Kikkawa Yumio,
Kitagawa Teruo,
Tanaka Shingo
Publication year - 1989
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1989.tb01269.x
Subject(s) - medicine , cytotoxic t cell , growth hormone , cd8 , hormone , monoclonal antibody , endocrinology , immunology , antibody , cancer research , immune system , biology , biochemistry , in vitro
We studied the immunomodulatory role of growth hormone (GH) treatment in GH‐deficient children. CH potentiated natural killer (NK)cell activity and the PHA and Con‐A lymphocytoproliferative response. Two‐color fluorescence using monoclonal antibodies (CLM, 2H4, CD8 and CD11) showed a moderate reduction of the helper T cells and NK cells, but no changes of suppressor T cells or cytotoxic T‐cells during GH therapy. Cancer and slow viral infection in GH‐deficient children have been watched for carefully before and after GH therapy.