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Plasma Concentrations of Atrial Natriuretic Peptide in Children with Persistent Hypertension
Author(s) -
Ito Yuhei,
Kinoshita Shouhei,
Kato Hirohisa,
Marumo Fumiaki,
Ando Kenji
Publication year - 1989
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1989.tb01263.x
Subject(s) - medicine , atrial natriuretic peptide , excretion , endocrinology , pathogenesis , sodium , fractional excretion of sodium , natriuretic peptide , essential hypertension , plasma concentration , blood pressure , heart failure , chemistry , organic chemistry
Plasma concentrations of human atrial natriuretic peptide (hANP) were determined in children with persistent hypertension and in age‐matched normotensive controls. We studied 40 children 6–7 years of age (Group A), and 74 children 13–14 years of age (Group B). There was no significant difference in plasma hANP concentration between hypertensives and normotensives in group A. In group B, the plasma hANP concentration in hypertensives (86.5 ±44.9 pg/ml: mean±SD) was significantly higher than in normotensives (58.8±40.4 pg/ml) (p <0.01). In group B, 24‐hour urinary excretion of sodium and fractional excretion of sodium were not significantly different between hypertensives and normotensives. The plasma hANP correlated significantly with the fractional excretion of sodium (p<0.05)and the 24‐hour urinary excretion of sodium (p<0.01) in normotensives. No such correlation was evident in the case of the hypertensives. The pathogenesis of increased plasma hANP concentration in older children with persistent hypertension remains to be investigated. In regard to the effects of hANP on renal function, hANP may contribute to the regulation of sodium handling in normotensive adolescents, whereas other regulatory mechanisms need to be considered in the case of hypertensives.