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Virological, Serological and Molecular Analysis of a Case with Congenital Cytomegalovirus Infection
Author(s) -
Eizuru Yoshito,
Takahashi Hirohiko,
Ueno Ichiro,
Minamishima Yoichi
Publication year - 1988
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1988.tb02557.x
Subject(s) - serology , medicine , cytomegalovirus , virology , in utero , antibody , restriction enzyme , human cytomegalovirus , fetus , endonuclease , cytomegalovirus infection , transmission (telecommunications) , antigen , immunology , virus , herpesviridae , pregnancy , viral disease , dna , biology , genetics , electrical engineering , engineering
Cytomegalovirus (CMV) was isolated concurrently from an infant and her mother on the 2nd day after delivery. Restriction endonuclease cleavage analysis of viral DNAs revealed that these two CMVs were identical. Sera from the infant and mother were both positive for IgM specific to CMV and antibody against early antigen (EA). Thus, virological, serological and molecular analysis indicated the transmission of CMV from a mother to her fetus in utero .