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Japanese Encephalitis Vaccine
Author(s) -
Oya Akira
Publication year - 1988
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1988.tb02516.x
Subject(s) - medicine , citation , japanese encephalitis , covid-19 , pediatrics , library science , encephalitis , family medicine , virology , disease , pathology , infectious disease (medical specialty) , virus , computer science
Japanese encephalitis (JE) is an inflammatory disease in central nervous organs including brain, cerebellum and spinal cord. The disease occurs with sudden fever, headache and stiffness of the neck. High fever continues and neurological symptoms such as coma, muscular rigidity, abnormal movements and pathological reflexes occur. The case fatality rate is 10 to 30%. However, neurological sequelae are noted in approximately half of the recovered cases. Thus complete cure is not to be expected in more than half of the cases. The etiological agent is JE virus which is one of the flaviviridae of the togavirus family. Man is infected with JE virus by mosquito bite. The main vector mosquito is Culex tritaeniorhynchus, seen in Japan commonly in the summer season. The vector mosquito transmits JE virus among domestic pigs causing a zoonosis in early summer. The amplified population of infected mosquitoes by the mosquito-pig transmission cycle attacks humans. The control of JE has been a problem in the endemic districts. Since the control of the vector mosquito is hardly to be expected, immunization of man seems t o be the sole available control measure of JE.