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Structure and Function of Interleukins 4 and 5
Author(s) -
Honjo Tasuku,
Yaoita Yoshio,
Kinashi Tatsuo,
Noma Yoshihiko,
Naito Takayuki,
Azuma Chihiro,
Severinson Eva,
Sideras Paschalis,
BergstedtLindqvist Susanna,
Takatsu Kiyoshi,
Tominaga Akira,
Harada Nobuhiko,
Tanabe Toshizumi,
Konishi Mikio,
Takahashi Masazumi,
Matsuda Fumihiko
Publication year - 1987
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1987.tb02237.x
Subject(s) - medicine , recombinant dna , function (biology) , growth factor , transforming growth factor , interleukin , microbiology and biotechnology , immunology , cytokine , gene , biochemistry , biology , receptor
We have cloned cDNAs for IgG, induction factor and T cell replacing factor. The recombinant factors were shown to have multiple activities on B cells, which could explain most, if not all, of B cell growth and differentiation factor activities so far claimed. Since the recombinant factors were also shown to affect bone marrow‐derived cells other than B cells, the names of interleukins 4 and 5 were proposed for IgG 1 induction factor and T cell replacing factor, respectively.