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Alternating Hyper‐ and Hypothyroidism with Thyroid‐Stimulating and TSH‐Binding Inhibition Immunoglobulins
Author(s) -
Sato Tamotu,
Miyagawa Kazuhiko,
Igarashi Noboru,
Kajiwara Sohei
Publication year - 1987
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1987.tb00392.x
Subject(s) - medicine , propylthiouracil , anti nuclear antibody , endocrinology , graves' disease , antibody , thyroid , titer , antithyroid drugs , immunology , autoantibody
The clinical course of Graves' disease is described in an 8 year old girl with high thyroid‐stimulating immunogloblin (TSI) and thyrotropin‐binding inhibition immunoglobulin (TBII) titers, 6,421% and 87.8%, respectively. She had three cycles of alternating hyper‐ and hypothyroidism during two years of observation with or without antithyroid medication or thyroxine replacement. She also developed a propylthiouracil‐induced lupus‐like syndrome with a positive antinuclear antibody. Although a causal relationship between elevated TSI and TBII titres and hyper‐hypothyroidism was not established, the coexistence of high TSI and TBII titres requires close observation for the proper treatment of this disorder.