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Chemical Mediator in Exercise‐Induced Asthma and Exercise‐Induced Late Asthmatic Responses
Author(s) -
Likura Yoji,
Nagakura Toshikazu,
Kondo Tomomi,
Odajima Yasuhei,
Walsh Garry M.,
Masaki Takuro,
Obata Toshihiko
Publication year - 1987
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1987.tb00364.x
Subject(s) - medicine , exercise induced asthma , mediator , histamine , asthma , leukotriene , physical exercise , chemotaxis , immunology , leukotriene b4 , endocrinology , inflammation , receptor
In this paper, we describe chemical mediator fluctuation in exercise‐induced asthma (EIA) and exercise‐induced late asthmatic responses (EILA). The moderate, severe patients who showed EIA, had statistically significant increased plasma histamine levels after exercise. Leukotriene (LT) release from polymorphonuclear leukocytes (PMN) showed two different patterns. In the EIA negative group, generation of LTs from PMN showed a significant increase after an exercise task. However, the EIA positive group showed statistically significant decreases at 15 minutes after exercise. In EILA, patients showed biphasic decreases in FEVi.o following exercise, which was accompanied by a parallel increase in neutrophil chemotactic activity (NCA).