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Intensive Insulin Therapy—Effects on M‐Value and Frequency of Hypoglycemia—
Author(s) -
Tanae Ayako,
Hashimoto Nobuko,
Kagawa Jiro,
Hibi Itsuro
Publication year - 1987
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1987.tb00333.x
Subject(s) - medicine , hypoglycemia , insulin , regimen , activities of daily living , anesthesia , endocrinology , physical therapy
The frequency of hypoglycemia and M‐values were measured on 11 intensively treated insulin dependent diabetic children separated into three groups of once‐daily, twice‐daily and multiple daily insulin injection regimens. Despite a similar quality of blood glucose control (Hb Al (%): 10.0 ± 1.5, 10.4 ± 2.6, 10.6 ± 2.5) in each of the above regimens, the M‐values were 26.2 ± 11.7 in the once‐daily, 34.9 ± 17.9 in the twice‐daily and 47.7 ± 14.7 in the multiple daily injection regimen (M ± SD), respectively. A mild biochemical hypoglycemia was found more often in the patients under treatment with twice‐daily and multiple daily injections. Further, though the mean blood glucose profiles in the patients treated with once‐daily and multiple daily injections were very good, marked hypoglycemic blood glucose levels were seen prior to meals, especially before lunch.