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High‐Dose Gammaglobulin Therapy in Six Children with Newly Diagnosed Insulin‐Dependent Diabetes Mel I it us
Author(s) -
Urakami Tatsuhiko,
Hanaoka Yoko,
Fujita Hidehiro,
Kitagawa Teruo
Publication year - 1987
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1987.tb00330.x
Subject(s) - medicine , gamma globulin , insulin , diabetes mellitus , gastroenterology , endocrinology , immunology , antibody
We treated six newly diagnosed children with insulin‐dependent diabetes mellitus (IDDM) with high‐dose gammaglobulin therapy in a clinical trial of immunomodulation. Approximately 400 mg/kg/day of polyethylene glycol‐treated gammaglobulin was given by intravenous injection for four to five days. After the initial therapy, four out of six patients showed an elevation of serum CPR and a decline of their insulin requirements; this indicates an improvement of insulin secretory function of pancreatic beta cells. A second course of gammaglobulin was given to four patients one year after the initial therapy, and the same results were observed in two out of four patients. These results suggest that high‐dose gammaglobulin might provide some protection against the deterioration of endogenous insulin secretion in children with IDDM.