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The Study of HLA, ICA and Autoantibodies in Japanese Type 1 Diabetes Mellitus
Author(s) -
Kida Kaichi,
Mimura Goto,
Kobayashi Tetsuro,
Nakamura Koichi,
Sonoda Shunro,
Inoue Hiroo,
Tsuji Kimiyoshi
Publication year - 1987
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1987.tb00328.x
Subject(s) - autoantibody , medicine , human leukocyte antigen , immunology , type 1 diabetes , haplotype , diabetes mellitus , islet , antigen , antibody , endocrinology , allele , genetics , gene , biology
HLA, ICA (islet cell antibody) and autoantibodies were studied in 65 Japanese patients with type 1 diabetes mellitus to elucidate the existence of immuno‐genetic heterogeneity. Patients with autoantibodies had increased frequencies of HLA DRw9 antigen and of HLA haplotype of Bw61‐DRw9, and a slow decay of ICA, while patients without autoantibodies had increased frequencies of HLA DR4 antigen and of HLA haplotype of Bw54‐DR4, and a rapid decay of ICA. These findings support the concept of immunogenetic heterogeneity in Japanese type 1 diabetes mellitus.