Premium
Effect of High‐Carbohydrate Diet on Lipid Metabolism in Young Type I Diabetics: Transient Changes in High‐Density Lipoprotein 2 and Lipoprotein Lipase
Author(s) -
Asayama Kohtaro,
Miyao Akiyo,
Bradley Charles A.,
Lorenz Rodney A.,
Kato Kiyohoko,
Burr Ian M.
Publication year - 1986
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1986.tb00769.x
Subject(s) - medicine , endocrinology , lipoprotein lipase , triglyceride , high density lipoprotein , lipoprotein , cholesterol , carbohydrate , lipase , lipid metabolism , carbohydrate metabolism , glycemic , insulin , enzyme , biochemistry , biology , adipose tissue
The short‐term effect of a high‐carbohydrate, low‐fat diet on lipoprotein metabolism was evaluated in eight young patients with type I diabetes mellitus. An isocaloric exchange diet containing 60% carbohydrate and 20% fat was administered for four weeks and serum lipid, high‐density lipoprotein and subfraction cholesterol, and the activity of the lipolytic enzymes in postheparin plasma were monitored. The assay methods for lipase activity and cholesterol concentration in high‐density lipoprotein subfractions were described previously. There were no appreciable changes in diabetic control, serum triglyceride and total cholesterol levels. The high‐density lipoprotein 2 cholesterol level decreased significantly after two weeks on the diet and returned toward baseline levels thereafter. There was a significant correlation between high‐density lipoprotein 2 cholesterol level and lipoprotein lipase activity. The high carbohydrate diet did not affect the glycemic control but induced a transient decrease in high‐density lipoprotein 2 cholesterol mediated by the decrease in lipoprotein lipase activity.