Premium
The Present Status of Sepsis of Children and Its Chemotherapy in Japan
Author(s) -
Meguro Hidenori,
Fujii Ryochi
Publication year - 1986
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1986.tb00751.x
Subject(s) - medicine , cefotaxime , ampicillin , sepsis , streptococcus pneumoniae , meningitis , gentamicin , haemophilus influenzae , ceftriaxone , staphylococcus aureus , etiology , antibiotics , pediatrics , microbiology and biotechnology , bacteria , genetics , biology
The present status of etiology and chemotherapy of sepsis of children in Japan is reported. In newborns and infants less than 3 months of age, the most common pathogens in sepsis and purulent meningitis are Escherichia coli and group B Streptococci, although Staphylococcus aureus becomes the second most important bacteremic pathogen after the 3rd day of life. In order infants and children, S. aureus, Haemophilus influenzae and Streptococcus pneumoniae are the most common bacteremic pathogens. Listeriosis is increasing in Japan, yet is responsible for only 1.4% of cases of purulent meningitis and 0.5% of sepsis in children at present. The chemotherapy of sepsis and purulent meningitis has been changed from the old standard ampicillin therapy (with gentamicin in neonates) to mono‐therapy with a new cephem, especially cefotaxime in Japan, since over 50% of strains of E. coli are already resistant to ampicillin.