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IgM Antibody to Core Antigen of Hepatitis B Virus in Vertical Transmission
Author(s) -
Yamanaka Tatsuru,
Tsuzuki Akiko,
Takayanagi Naoki,
Chiba Shunzo,
Chiba Yasuo,
Nakao Tooru
Publication year - 1986
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1986.tb00732.x
Subject(s) - medicine , hepatitis b virus , antibody , transmission (telecommunications) , virology , antigen , immunology , cord blood , hepatitis b , virus , immune system , electrical engineering , engineering
Transmission of hepatitis B virus (HBV) from a mother to the child is mostly due to infection during delivery. It has been suggested, however, that intrauterine HBV infection can occur in a small number of subjects. In the present study, we examined IgM antibody to core antigen of HBV (IgM‐HBcAB) in cord blood to see whether intrauterine infection could be distinguished from neonatal transmission of HBV. Infants with possible intrauterine infection, however, did not have IgM‐HBcAb in cord blood. It is concluded, therefore, that examination of this antibody is not useful for such purposes. IgM‐HBcAb may not be produced during the period when immune tolerance to HBV is maintained, since it was detected only in association with occurrence of liver cell injury.