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Causes of Failure in Prevention of Vertical Infection by Hepatitis B Virus
Author(s) -
Shiraki Kazuo,
Tanimoto Kaname,
Yamada Kazuhito,
Okada Takayoshi
Publication year - 1986
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1986.tb00730.x
Subject(s) - medicine , hepatitis b immune globulin , hepatitis b virus , vaccination , virology , hepatitis b , hepatitis b vaccine , immunology , virus , immunization , hepatitis , antigen , pediatrics , hbsag
In order to prevent the hepatitis B virus carrier state, 190 infants born to hepatitis‐Be antigen positive hepatitis‐B surface antigen carrier mothers were treated with hepatitis‐B hyperimmune globulin(HBIG) and hepatitis‐B vaccine after birth; however, 8 infants(4.2%) ultimately became carriers. There were three different causes for the failure, namely 1) prenatal infection, 2) insufficiency of HBIG to neutralize the virus transmitted, and 3) poor responsiveness of the infant to the vaccine. The present study suggests that early vaccination in the neonatal period increases the rate of poor responders as compared to later vaccination.