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Combined Passive and Active Immunization for Preventing Perinatal Transmission of Hepatitis B Virus Carrier State
Author(s) -
Tada Hiroshi,
Yanagida Masahiko,
Mishina Jun,
Sato Noriko,
Aihara Shinobu,
Baba Kiyoshi,
Mayumi Makoto
Publication year - 1986
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1986.tb00729.x
Subject(s) - medicine , immunization , hbeag , hepatitis b virus , transmission (telecommunications) , hepatitis b , pediatrics , vaccination , schedule , virology , virus , immunology , antibody , hbsag , electrical engineering , engineering , computer science , operating system
With the intravenous and intramuscular injection of HBIG followed by repeated vaccinations, of 223 infants born to HBeAg‐positive HBV carrier mothers, 215 infants were prevented from developing HBV carrier state during a follow‐up period of longer than 12 months. The protective efficacy rate was 95.6%. During this study, four infants developed HBs antigenemia before the completion of the immunoprophylaxis schedule, and five after the completion of the schedule. Possible preventive methods for these infants for the ultimate prevention of persistent HBV infection are discussed.