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The Rate of Clonal Transformation of B‐Lymphocytes by Epstein‐Barr Virus in Childhood
Author(s) -
Furukawa Toshiharu,
Kaiga Kazuhiro,
Takahashi Hiroshi,
Sugita Kenichi,
Eguchi Mitsuoki
Publication year - 1986
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1986.tb00713.x
Subject(s) - medicine , cord blood , virus , epstein–barr virus , ataxia telangiectasia , immunology , trisomy , virology , biology , genetics , dna , dna damage
Abstract The rate of clonal transformation of the B‐lymphocyte by Epstein‐Barr virus (EBV) in children was studied in semisolid agar culture. A remarkable influence of the cell donor's age on the rate was found: In the order of age, the rate was highest in cord blood, lower in infants, lowest in young children, somewhat higher in school children and high in adults. The rate of EBV‐associated nuclear antigen (EBNA)‐positive cells 24 h after infection showed little age‐dependent difference. The only significant difference was found between cord blood and young children. From these results, the age‐dependent difference in the rate of clonal transformation seemed to be mainly in the process after EBNA expression through transformed cell colony formation. In the children with trisomy 21 or ataxia‐telangiectasia, who have a high risk of leukemia or malignant lymphoma, the rate of clonal transformation was not higher than in age‐matched control groups.