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Neutrophil Receptors
Author(s) -
Ito Setsuko,
Mikawa Haruki
Publication year - 1985
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1985.tb00681.x
Subject(s) - immunoglobulin e , receptor , medicine , chemotaxis , phagocytosis , antibody , immunology , staphylococcus aureus , microbiology and biotechnology , immune system , biology , bacteria , genetics
We studied two interesting patients with neutrophil dysfunction: one is a patient with hyper‐IgE syndrome with the serum inhibitor which belongs to IgE class and the other is characterized by defective phagocytosis confined to S. aureus . These patients suggested to us the presence of IgE receptors and receptors for S. aureus on neutrophils. The presence of IgE receptors on neutrophils was proved by the fact that neutrophils preincubated with 10 μg of pure IgE generated O ‐ 2 on stimulation with F(ab') 2 , fragments of pure anti‐K chain antibody or anti‐K chain antibody. The presence of IgE receptors was also suggested by the suppressive effect of IgE soluble immune complexes on neutrophil chemotaxis. Neutrophils of the patient with defective phagocytosis confined to S. aureus could not generate O ‐ 2 with unopsonized S. aureus , while control neutrophils generated a significant amount of O ‐ 2 on addition of unopsonized S. aureus . Colchicine treated control neutrophils also could not generate O ‐ 2 by unopsonized S. aureus . These data suggested the presence of receptors for S. aureus on neutrophils.