Premium
Defective Opsonization Induced by Chemotherapy in Children With Leukemia or Lymphoma
Author(s) -
Ueno Norihiro,
Matsumoto Shuzo
Publication year - 1985
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1985.tb00677.x
Subject(s) - medicine , antibody opsonization , opsonin , chemotherapy , leukemia , complement system , lymphoma , immunology , phagocytosis , cancer research , oncology , antibody
Complement‐mediated opsonin activity was measured by the whole blood chemiluminescence method in 17 children with leukemia and lymphoma (6 with ALL, 7 with ANLL and 4 with non‐Hodgkin's lymphoma) during remission induction therapy. The opsonin activity, which was at the normal level before chemotherapy, was decreased in all of the children during the therapy. This decrease was especially remarkable in the children treated with L‐asparaginase. When the opsonin activity was decreased, the activities of other complement systems (C3, CH50) were also damaged. Among these activities, the opsonin activity was best maintained.