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Cytochrome B 558 Component of O ‐ 2M Generating Oxidase in the Neutrophils From Patients With Chronic Granulomatous Disease
Author(s) -
Takayanagi Naoki,
Niida Yuichi,
Chiba Shunzo,
Nakao Tooru
Publication year - 1985
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1985.tb00673.x
Subject(s) - chronic granulomatous disease , cytochrome c oxidase , cytochrome , cytochrome b , medicine , oxidase test , cytochrome c , absorption (acoustics) , nadph oxidase , microbiology and biotechnology , biochemistry , enzyme , immunology , chemistry , mitochondrion , biology , gene , physics , optics , oxidative stress , mitochondrial dna
Cytochrome b 558 is probably a component of an electron transport chain which is called NADPH oxidase. Cytochrome b 558 from the neutrophils of two male patients with chronic granulomatous disease (CGD) and their parents was studied. One of the CGD patients had decreased amounts of cytochrome b 558 , The α‐band of light absorption of cytochrome b 558 at 558 nm was found as a trace, and the peak of the γ‐band was shifted to 420 nm, whereas the normal γ‐band is at 426 nm. Intermediate amounts of cytochrome b 558 were present in his mother, whereas his father had a normal amount. Another patient had normal peaks of α‐ and γ‐bands of cytochrome b 558 . Thus, abnormalities in NADPH oxidase of the two patients were different.