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A Case of Transient Neonatal Hypothyroidism due to an Organification Defect of Iodide
Author(s) -
Ono Seigo,
Jitosho Tamotsu,
Maeda Shizuhiko,
Miyata Koichiro
Publication year - 1985
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1985.tb00667.x
Subject(s) - organification , medicine , thiocyanate , iodide , thyroid , congenital hypothyroidism , endocrinology , iodine , myxedema , pediatrics , biochemistry , chemistry , materials science , organic chemistry , metallurgy
The patient was the product of fullterm pregnancy with no complication. The screening TSH result was high (134 μ U/ml) at five days of age, and low T 3 (1.37 ng/ml) and T 4 (1.2 μ g/dl) levels were detected at 23 days of age. The thyroidal 123 I‐uptake and the thiocyanate discharge test revealed that the cause of her thyroid insufficiency was an organification defect of iodide. Remission occurred during therapy, and the repeated thyroidal 123 I‐uptake and the thiocyanate discharge test showed improvement. She had no other factor which has been previously reported and could have caused the transient hypothyroidism. This case supports the hypothesis that the cause of transient neonatal hypothyroidism is a delay in the maturation of the enzymatic mechanisms involved in intrathyroidal hormonogenesis.