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Susceptibility of Group B Streptococci to 30 Antibiotic Including New Cephalosporins.
Author(s) -
Fujita Kozo,
Murono Koichi,
Sakata Hiroshi,
Yoshioka Hajime
Publication year - 1985
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1985.tb00642.x
Subject(s) - microbiology and biotechnology , cefotaxime , cephalosporin , benzylpenicillin , medicine , ampicillin , cefuroxime , penicillin , cephaloridine , minimum inhibitory concentration , tetracycline , antibiotics , lincomycin , biology
The in vitro susceptibility of 32 group B streptococci, isolated from infants with systemic infections, to 30 antibiotics including new cephalosporins was studied. Benzylpenicillin, having the minimal inhibitory concentration (MIC) of 0.063 μg/ml, was the most active agent among the penicillins tested, and ampicillin, having an MIC of 0.063–0.125 μg/ml, was almost as active as benzylpenicillin. Cephalosporins had a wide range of activities, but such cephalosporins as cefmenoxime (MIC of 0.032–0.063 μg/ml), cefuroxime, cefotaxime and ceftriaxone (MIC of 0.063–0.125 μg/ml), were equally or more active than benzylpenicillin or ampicillin. Latamoxef with an MIC of 8–16 μg/ml was least active among the cephalosporins tested. Kanamycin and amikacin, having MICs of 128 or more than 128 μg/ml, were far less active than gentamicin (MIC of 8–32 μg/ml) and tobramycin (MIC of 16–32 μg/ml). 31 and 72% of isolates were resistant to chloramphenicol and tetracycline respectively, but only one strain was resistant to erythromycin and lincomycin. The strains resistant to tetracycline and chloramphenicol were prevalent in the subtypes III and III/R group B streptococci.