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The Effects of Anti‐Thymus Serum on Embryonic Development in the Rat
Author(s) -
Miyata Koichiro,
Jitosho Tamotsu,
Tachikura Junko,
Haraguchi Tsutomu,
Suenaga Shinji
Publication year - 1984
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1984.tb01854.x
Subject(s) - medicine , resorption , hypoplasia , gestation , endocrinology , fetus , pregnancy , andrology , biology , genetics
Pregnant Wistar rats were injected with rabbit anti‐rat‐thymus serum (ATS) alone or in combination with rabbit anti‐rat‐heart serum (AHS). The results showed that the percentage of malformation was low (5.7 to 7.5%) when doses over 0.6 ml/100 g of ATS were administered; resorption was 23.2 to 28.4%. However, the incidence of malformations markedly increased to 28.9% when a dose (0.9 ml/100 g) of ATS was given on day 9 of gestation followed by 0.9 ml/100 g of AHS on day 10. The resorption and cardiovascular malformations were 39.7% and 10.5%, respectively. These results suggest that ATS potentiates teratogenicity in combination with AHS, though hypoplasia of thymus was not observed.