Premium
T Cell Subset and Steroid Sensitivity in Idiopathic Nephrotic Syndrome in Children
Author(s) -
Takahashi Yoshihiro
Publication year - 1984
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1984.tb01850.x
Subject(s) - medicine , idiopathic nephrotic syndrome , peripheral blood , rosette formation , nephrotic syndrome , endocrinology , receptor , steroid , rosette (schizont appearance) , t cell , peripheral , immunology , suppressor , proteinuria , immune system , kidney , hormone , cancer
The relationship between T cell subset of peripheral blood lymphocytes and steroid sensitivity was studied in children with idiopathic nephrotic syndrome (INS). The subjects were 28 INS children, aged 2 to 16 years. T cells bearing receptors for IgG (Tγ) were identified by double rosette assay with sheep erythrocytes and IgG‐sensitized ox erythrocytes. T cells bearing receptors for IgM (Tμ) were identified by IgM‐sensitized ox erythrocytes rosette assay in purified T cells after incubating overnight. In steroid sensitive INS children, decreased numbers of Tγ cells and increased numbers of Tμ cells in onset or relapse were found and they were normalized with corticosteroid administration. Tγ cells of steroid nonsensitive INS children remained decreased even after steroid therapy. Tγ cells have been suggested to be, at least in part, suppressor T cells. Alteration of peripheral blood Tμ cells in this observation therefore may suggest the abnormality of suppressor T cells in INS children.