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HLA in Japanese Insulin‐Dependent Diabetes Mellitus
Author(s) -
Juji Takeo,
Maeda Hiroo,
Tokunaga Katsushi,
Ishiba Shintaro,
Maruyama Hiroshi
Publication year - 1984
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1984.tb01827.x
Subject(s) - medicine , haplotype , diabetes mellitus , human leukocyte antigen , insulin dependent diabetes , immunology , gene , endocrinology , genetics , allele , autoimmune disease , antigen , disease , biology
Ninety‐four Japanese patients with insulin‐dependent diabetes mellitus (IDDM) and 388 healthy randomly selected Japanese were HLA typed. Significantly increased frequencies of Bw54, Cwl, DR4, B17 (Bw58), DR3 and DRw9 were observed. Simultaneously, the frequencies of Bw52 and DR2 in the patients were found to be significantly low as compared with those in helathy Japanese controls. It was suggested that one of the susceptibility genes to IDDM, which is associated with B8, DR3 haplotypes in Caucasoids, might be associated with B17 (Bw58), DR3 haplotypes in Japanese and in Chinese. Another susceptibility gene to IDDM associated with DR4 in Caucasoids might be associated with both DR4 and DRw9 in Japanese. A very rare variant of properdin factor B allotypes (BF*FT or BF*F075) was shown to be associated significantly with Japanese IDDM and with Bw52, DRw9 haplotypes.