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A Comparative Study on the Epidemiology of IDDM Between Japan, Norway, Israel and the United States
Author(s) -
Kitagawa Teruo,
Fujita Hidehiro,
Hibi Itsuro,
Aagenaes ØYstein,
Laron Zvi,
Laporte Ronald E.,
Tajima Noriko,
Drash Allan L.
Publication year - 1984
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1984.tb01825.x
Subject(s) - medicine , incidence (geometry) , epidemiology , demography , significant difference , pediatrics , physics , sociology , optics
Japn, Norway, Israel and the United States have studied have studied the epidemiology of IDDM in children by a similar method of data collection. Afterwards, the data were compared. Available data demonstrated that children in Norway, the United States and Israel were almost 20,15 and 5 times more likely respectively to develop IDDM than children in Japan. Although there was a samll difference in sex ratio, incidence in the smaller age group, and incidence of slowly progressing type IDDM between Japan and the other three countries, the other descriptive epidemiology of IDDM was quite similar, despite the large difference in the incidence and prevalence of IDDM. Therefore, it seems that the difference in the incidence would not be primarily environmental and could be related to the number of individuals susceptible to diabetes. It was hypothesized that the difference in incidence may be linked to the difference in prevalence of HLA type among the children in those four countries. However, it cannot be fully explained nby HLA difference. Other genetic markers associated with the developing IDDM musrt be evaluated.