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Clinical Pharmacokinetics of Nitrazepam in Childhood Epilepsy
Author(s) -
Katafuchi Yukihiko,
Aoki Noboyuki,
Matsuishi Toyojiro,
Yamashita Fumio
Publication year - 1984
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1984.tb01814.x
Subject(s) - medicine , nitrazepam , phenobarbital , anticonvulsant , epilepsy , pharmacokinetics , drug , serum concentration , pharmacology , gastroenterology , diazepam , psychiatry
Steady state serum levels of nitrazepam (NZP) in 60 epileptic children ranging in age from 6 months to 18 years with various types of epilepsy were investigated by high‐pressure liquid chromatography. Also studied were the influence of age on the serum NZP level and the drug interaction of phenobarbital (PB) or sodium valproate (VPA). Serum half‐lives of NZP were also calculated in 9 epileptic children under long‐term treatment. A significant correlation (r=0.683, p