Premium
Comparison of New Sustained‐Release Theophylline (E‐0686) and Theo‐Dur
Author(s) -
Masaki Takuro,
Nagakura Toshikazu,
Inui Hiroyuki,
Umesato Yoshihiro,
Obata Toshihiko,
Likura Yoji
Publication year - 1983
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1983.tb01717.x
Subject(s) - theophylline , medicine , pharmacology , anesthesia
New sustained‐release theophylline (E‐0686) was administered to asthmatic children to study changes in serum theophylline level and its reproducibility. Results are as follows:1) t‐Max. of E‐0686 was shorter than that of Theo‐Dur, however, E‐0686 could maintain a satisfactory serum theophylline level at 12 hours on a single dose. 2) A steady state was reached after three days on a multiple dose of E‐0686. P‐T difference of E‐06 was 5.17 μg/ml, which could be sufficient for sustained‐release theophylline. 3) Changes in serum theophylline level of E‐0686 was highly reproducible.