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Early Diagnosis of Wheezing Infants
Author(s) -
Akasaka Toru
Publication year - 1983
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1983.tb01716.x
Subject(s) - medicine , bronchiolitis , asthma , pediatrics , wheeze , allergy , acute bronchiolitis , eosinophilia , prospective cohort study , incidence (geometry) , family history , respiratory sounds , immunology , respiratory system , physics , optics
Abstract One hundred wheezy infants were diagnosed by “Asthma Prospective Score” initially and followed for 5 years. The score consists of major criteria (1) family history of major allergies, (2) high serum IgE level and minor criteria 1 family history of minor allergies, 2 age of onset after 6 months, 3 wheeze between March and October, 4 other allergic signs, 5 eosinophilia in the nasal smear, 6 remarkable improvement by the subcutaneous epinephrine. The infants with either two major criteria or one major and 3 or more minor criteria were diagnosed as asthma and less than these as bronchiolitis prospectively. There were significantly higher incidence of atopic family, high IgE, age of onset and other allergic signs (P<0.01), and response to epinephrine (P<0.02). And good correlation was found between diagnosis based on this score and final diagnosis, 61 out of 66 asthmatics (92.4%) and 27 out of 34 bronchiolitis group (79.4%). It is concluded that this scoring system could help us to make the diagnosis of asthma in early infancy.