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Histamine suppression of the non‐immunological release of slow reacting substances from neutrophils of asthmatics
Author(s) -
Torii Shimpei,
Kishimoto Machiko,
Katagiri Masanori,
Yamada Masanori
Publication year - 1983
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1983.tb01710.x
Subject(s) - cimetidine , histamine , medicine , zymosan , cytochalasin b , incubation , theophylline , antagonist , pharmacology , immunology , histamine h4 receptor , receptor , histamine h2 receptor , biochemistry , in vitro , chemistry
Slow reacting substance is released from cytochalasin B treated human polymorphonuclear leukocytes by incubation with zymosan and fresh autologous serum. It is reversed by FPL 55712, a specific endorgan antagonist of SRS‐A and the process is confirmed to involve LTC 4 , LTD 4 , LTE 4 by High‐Performance Liquid Chromatography. The levels of SRS from PMN by the non‐immunological stimuli are significantly higher in asthma group than in control group. SRS is inhibited with pretreatment of theophylline and histamine, and the suppressed release of SRS is recovered by adding cimetidine, H2‐brocker. Histamine appears to inhibit SRS release through H2‐receptor. The role of neutrophils in IgE mediated hypersensitivity was discussed.