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Lymphocytes with receptor for Peanut Agglutin in Wiskott‐Aldrich syndrome
Author(s) -
Mizutani Shuki,
Sei Akuhi,
Iwata Tsutomu,
Akagi Kunihiko,
Kaneshi Kunio,
Bessho Fumio,
Kobayashi Noboru
Publication year - 1983
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1983.tb01703.x
Subject(s) - wiskott–aldrich syndrome , peanut agglutinin , wiskott–aldrich syndrome protein , medicine , immune system , immunology , receptor , soybean agglutinin , agglutinin , cell , biology , genetics , lectin , gene , cytoskeleton , actin cytoskeleton
The Wiskott‐Aldrich syndrome is a sex‐linked recessive disorder characterized by having defective T‐cell function and poor antibody response. We have investigated the percentage of lymphocytes with receptor for Peanut Agglutinin in four children of Wiskott‐Aldrich syndrome. We discovered an increase in percentage of the lymphocytes with receptors for Peanut Agglutinin in all Wiskott‐Aldrich syndrome except one. Our findings suggested that the increase in percentage of Peanut Agglutinin positive cells in Wiskott‐Aldrich syndrome may reflect degree of immune deficient state, and one of primary or secondary abnormalities of this immunological disorder.