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Coronary Blood Flow Changes in Acute Left Ventricular Obstruction in Anesthetized Dogs
Author(s) -
Lagarashi Katsuro
Publication year - 1983
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1983.tb01700.x
Subject(s) - medicine , cardiology , ventricle , blood flow , aortic pressure , balloon , balloon catheter , pressure gradient , blood pressure , hemodynamics , aorta , afterload , physics , mechanics
Short term studies were carried out analyzing the degree of ischemia, based on coronary blood flow, associated with infravalvular obstruction in relation to increments in leftventricular peak systolic pressure overload. In these experiments a double lumen balloon catheter was placed in the infravalvular region of the left ventricle through the apex; the balloon was then inflated slowly with saline solution to make systolic pressure gradients between left ventricle and aorta gradually up to 60mmHg. There was an inverse relationship between coronary blood flow and the gradient between left ventricular peak systolicpressure(P lv )and aortic pressure (P ao ); when the P lv –P ao gradient was plotted as a function of coronary blood flow a linear regression slope with a value of ‐0.3 was obtained. At a maximal P lv –P ao gradient pressure of 60mmHg, coronary blood flow decreased 20%. When coronary blood flow was plotted as a function of PLV the linear regression slope was –0.4 and as a function of P ao the value for the slope was 0.79. (P