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Chromosomal Analysis of Childhood Acute Lymphoblastic Leukemia: As a Routine Examination for Diagnosis and Prognosis
Author(s) -
Shikano Takaaki,
Ueno Norihiro,
Matsumoto Takahide,
Ohkawa Masato,
Tonooka Tatsuhito
Publication year - 1983
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1983.tb01690.x
Subject(s) - medicine , leukocytosis , chromosomal translocation , leukemia , chromosomal analysis , lymphoblastic leukemia , risk factor , abnormality , pediatrics , complete remission , karyotype , chromosome , chemotherapy , gene , biochemistry , chemistry , psychiatry
Chromosomal analysis was performed as a routine examination for diagnostic and prognostic evaluation of children with acute lymphoblastic leukemia (ALL) in six cases encountered during a one‐year period. The results obtained are as follows. 1. Chromosomal abnormality of leukemic cells was observed in five out of six cases (approximately 80%). 2. Translocation 4; 11 or 14q+, which are known as a risk factor of ALL, were observed in three patients. Two of three patients died within six months of the onset of disease. One case was diagnosed as congenital leukemia with remarkable leukocytosis, and the other case was accompanied by hypereosinophilic syndrome. The remaining one patient, who is now in complete remission, is 13 years old, which is within the period of risk ages exceeding 10 years of age. 3. The case with 1q+ had no risk factor; however, he had a relapse 19 months after the diagnosis. Thus this particular chromosomal rearrangement appeared to be one of the risk factors. 4. The case with 6q‐, which has been reported to have a good prognosis in some cases of ALL, has no risk factor, and has been in complete remission. These results seem to confirm the usefulness of chromosomal analysis for the evaluation of the clinical course of ALL.