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Mite Antigen in Kawasaki Disease
Author(s) -
Furusho Kenshi,
Sato Katsuko,
Soeda Takeshi,
Kimoto Keiichi,
Okabe Takahiro,
Hirota Tsuneo,
Sasai Kazuhiko,
Tani Shigeki
Publication year - 1983
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1983.tb01680.x
Subject(s) - mite , medicine , immunology , immunoglobulin e , antigen , radioallergosorbent test , house dust mite , fluorescein isothiocyanate , antibody , biology , botany , physics , quantum mechanics , fluorescence
The relation between house dust mite antigen and Kawasaki disease (KD) wasexamined immunologically in 60 patients with KD.1) In most patients, the serum IgE was significantly raised during the acute phase of the disease and fell gradually during convalescence. 2) Although anti‐mite ( Dermatophagoides pteronyssinus ) specific IgE (RAST) values during the illness were significantly raised in only 15 patients (25%) when expressed as RAST scores, there was a correlation between serum IgE and anti‐mite specific IgE (expressed as counts/min) (r=0.56; p<0.01). 3) An intradermal skin test on reactivity to mite antigen gave positive or false‐positive in 34 of 60 patients (57%) transiently or persistently during the illness. 4) The serum levels of anti‐mite ( D.pteronyssinus ) specific IgG were estimated by the IgG RAST method. In 15 of 20 patients (75%) RAST values were persistently or transiently high. 5) The presence of mite antigen in circulating immune complexes in the patients was examined by Raji cell assay and the direct fluorescein isothiocyanate labelled anti‐mite rabbit gammaglobulin method. In three of eight patients specific fluorescence was seen on the surface of cells. 6) The proliferative responses of lymphocytes to mite ryltigen and phytohaemaglutinin (PHA) were examined in six patients. The response to mite antigen of lymphocytes from the patients was significantly higher than those of age‐matched controls (p<0.0.1). 7) More mite ( Dermatophagoides spp ) were found in house dust collected from the homes of 12 patients than in that of dust from 10 control homes (p<0.0 1).These results support the hypotheses that mite antigen may invade the body via the upper respiratory tract and act as a respiratory allergen and form circulating immune complexes, resulting in an immune copledx disease such as vasculitis.