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Studies on the Enterohepatic Circulation of Bile Acids in Infancy and Childhood
Author(s) -
Arisaka Osamu
Publication year - 1981
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1981.tb01647.x
Subject(s) - enterohepatic circulation , medicine , taurine , bile acid , gastroenterology , chenodeoxycholic acid , biliary atresia , glycine , cholestasis , endocrinology , biochemistry , amino acid , chemistry , transplantation , liver transplantation
To elucidate the effects of free chenodeoxycholic acid (CDC) and glycine and taurine conjugated CDC on the enterohepatic circulation, these 3 forms of CDC were injected into the portal vein of rabbits with bile fistula, and bile flow, total bile acid level in bile and serum were successively determined for 3 hours. Bile acids injected were Glycine‐CDC (8 cases), Taurine‐CDC (8 cases) and free CDC (8 cases). As the control (5 cases), 0.45% NaCl solution was injected. The total bile acid level was measured by enzymatic fluorometry. These 3 forms of CDC more or less induced cholestasis, and the cholestatic effects were stronger in descending order as follows: Free CDC > T‐CDC > G‐CDC. The present study suggested that the toxicity of CDC primarily or secondarily concentrated might injure the hepatobiliary system in children and play a role in the incidence and progress of neonatal hepatitis, congenital biliary atresia or other hepatobiliary disorders. (Acta Paediatr Jpn 23(3):353–361 1981)