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Periosteal Hypertrophy Following Administration of Prostaglandin E 1 : Biopsy Findings
Author(s) -
Sato Yuichi,
Okishima Takahiro,
Matsuoka Yuji,
Yamamoto Kazuhiro,
Sennari Eiichi,
Hayakawa Kunio
Publication year - 1980
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1980.tb00533.x
Subject(s) - medicine , periosteum , muscle hypertrophy , resorption , biopsy , ventricle , prostaglandin e , prostaglandin , tibia , surgery
Since prostaglandin E 1> (PGE 1 ) has been used for congenital cyanotic heart diseases of PDA‐dependent type due to its ductus dilatation effect, it is now possible to perform shunt operations with recovery of the general condition. Simultaneously, however, various side effects have been reported. In recent years, periosteal hypertrophy has been attracting attention as a side effect after long‐term administration of PGE 1 . In this study, the authors administered 0.03 μg/kg/min of PGE 1 intravenously to an infant with a single ventricle and pulmonary atresia from the 7th day after birth. On the 9th day after the onset of administration, swelling and pain appeared in the lower limbs and later in the upper limbs. X‐rays of the lesions revealed hypertrophy of the periosteum. After administering PGE 1 for 98 days, a shunt operation was performed, and a biopsy of the right tibia was conducted. Microscopic examination of the biopsy specimen showed marked new osteogenesis due to woven bones, and resorption, including osteoclasts, presumably attributable to a reaction specific to woven bones.