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“Pulse” Methylprednisolone Therapy in the Treatment of Idiopathic Thrombocytopenic Purpura: A preliminary Report
Author(s) -
Takayama Yoichi,
Ouchi Toru,
Iwai Asayuki,
Iwai Tsuyako,
Ninomiya Tsuneo,
Miyao Masuhide,
Yoshida Shigehiko
Publication year - 1980
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1980.tb00532.x
Subject(s) - medicine , thrombocytopenic purpura , methylprednisolone , regimen , splenectomy , platelet , hormone therapy , surgery , spleen , cancer , breast cancer
Pulse‐mode methylprednisolone therapy was instituted in the treatment of idiopathic thrombocytopenic purpura (ITP), both acute and chronic forms. This regimen induced a rapid increase in the platelet count in a short time and was less toxic than the conventional mode of therapy, i.e. oral steroid hormone administration. This regimen is of value in the management of patients with ITP who are at the substantial risk of fatal hemorrhage. And this is also useful as a short‐term presplenectomy preparation or as a “medical splenectomy” program. Impressive responses in our experience encouraged us to evaluate this mode of therapy.