One Aspect of Immunoregulatory Mechanism during the Fetal Period on the Immunosuppressive Effect of α‐fetoprotein 1 | Zendy

Ito S. | Zendy; Yoshino K. | Zendy; Okitsu S. | Zendy; Ushijima H. | Zendy; Hashira S. | Zendy; Hashimoto G. | Zendy; Fujii R. | Zendy

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One Aspect of Immunoregulatory Mechanism during the Fetal Period on the Immunosuppressive Effect of α‐fetoprotein 1

Author(s) -

Ito S.,

Yoshino K.,

Okitsu S.,

Ushijima H.,

Hashira S.,

Hashimoto G.,

Fujii R.

Publication year - 1980

Publication title -

pediatrics international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.49

H-Index - 63

eISSN - 1442-200X

pISSN - 1328-8067

DOI - 10.1111/j.1442-200x.1980.tb00510.x

Subject(s) - immunosuppression , medicine , in vitro , fetus , mechanism (biology) , immunology , t lymphocyte , period (music) , andrology , immune system , biology , pregnancy , biochemistry , genetics , philosophy , epistemology , physics , acoustics

The effect of AFP on in vitro anti‐SRBC PFC response was evaluated in order to clarify the mechanism by which the immunosuppressive activity of AFP was exerted. T/μ and Tγ cells were precultured with AFP and these precultured cells were added to the in vitro lymphocyte culture system. Anti‐SRBC PFC response was more significantly inhibited with the addition of AFP‐precultured Tμ cells than with AFP‐precultured Tγ cells. These results indicated that the immunosuppressive activity of AFP might be mediated by Tμ (helper T) cells. The possible mechanism of immunosuppression during the fetal and neonatal periods are discussed.

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