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Developmental Maturations of B Cell Differentiation Ability and T Cell Regulatory Function in Man 1
Author(s) -
Miyawaki T.,
Moriya N.,
Nagaoka T.,
Yachie A.,
Taniguchi N.
Publication year - 1980
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1980.tb00505.x
Subject(s) - medicine , pokeweed mitogen , immunology , concanavalin a , cellular differentiation , cord blood , b cell , suppressor , cell , microbiology and biotechnology , antibody , biology , genetics , gene , in vitro , cancer
As assessed in Nocardia mitogen system, B cell differentiation ability and T cell help for IgM‐production appeared to be nearly maturated at birth, but those for IgG‐ and IgA‐production were still deficient in cord blood and required much more time for their maturation. Deficit in concanavalin A‐inducible humoral suppressor activity and marked excess in pokeweed mitogen‐inducible one were peculiar properties of T cells in the early developmental period of life. The T cell subset in cord blood defined by OKT4 monoclonal antisera was much more suppressive on B cell differentiation than did another OKT8 + subset, suggesting functional aberration of cord T cell subsets from corresponding adult ones.