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A Study of HLA in Japanese Patients with Rheumatic Fever
Author(s) -
Naritomi Kenji,
Yoshifumi Kawano,
Miyazaki Hiroshi,
Hokonohara Masashi,
Miyata Koichiro,
Terawaki Tamotu
Publication year - 1980
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1980.tb00500.x
Subject(s) - medicine , rheumatic fever , human leukocyte antigen , linkage disequilibrium , immunology , rheumatic disease , antigen , genotype , gene , haplotype , rheumatoid arthritis , genetics , biology
HLA was analysed to study an aspect of genetic background of susceptibility to rheumatic fever. The frequency of HLA was determined in 66 Japanese patients with rheumatic fever and compared with 95 healthy Japanese controls by chi‐square method with Yates' correction. The frequency of Bw35 was increased significantly in rheumatic fever group compared with control group (Pc < 0.01). An association between Bw35 and rheumatic fever may imply that rheumatic fever is an autoimmune disease. And the susceptibility to rheumatic fever may be controlled by immune response genes, which have a linkage disequilibrium with Bw35 as an immunogenetic background.