Premium
Secretin Secretion in Infancy and Childhood. Part 1. Plasma Secretin Levels in Infants and Children
Author(s) -
Yamamoto Koichi
Publication year - 1980
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1980.tb00497.x
Subject(s) - secretin , medicine , radioimmunoassay , endocrinology , umbilical cord , plasma levels , weaning , fetus , secretion , pregnancy , biology , immunology , genetics
In order to elucidate the development of secretin secreting ability in children, plasma secretin levels of children (361 cases), pregnant women (11 cases) and umbilical cord blood samples (35 samples) were measured by double‐antibody radioimmunoassay method using 125 I‐[Tyr 1 ] ‐secretin as tracer.1) Maternal plasma secretin level immediately before delivery was significantly higher than those of cord plasma and there was no correlation between the two types of plasma levels. Accordingly, it was thought that secretin can not transfer through the placenta from mother to fetus. 2) Between cord arterial and venous plasma secretin levels, there was a positive correlation (p < 0.005, r = 0.5863, n = 19) and the difference was not significant. 3) Plasma secretin levels increased gradually for a week after birth and the plasma secretin level on the seventh day was significantly higher than that on the first day (p < 0.04). 4) Plasma secretin levels in infants lowered a little up to the fourth month but rose again from the fifth month. It was considered that this rise was due to the influence of the initiation of weaning. 5) In children and school‐children, plasma secretin levels increased rapidly at five years of age and thereafter they showed near adult values or a little higher. It was thought that secretin secreting ability matures at approximately 5 years of age. 6) The mean plasma secretin levels in childhood appeared paralleling fairly well the growth of gastric acid secreting ability.