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Studies on Fc Receptor Bearing T Cells in Infectious and Immunological Diseases of Children: Part 2. Fc Receptor Bearing T Cell in Bronchial Asthama and Renal Diseases
Author(s) -
Watanabe Akiko
Publication year - 1980
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1980.tb00258.x
Subject(s) - medicine , receptor , bearing (navigation) , immunology , pathology , cartography , geography
Receptor for the Fc portion of IgG (FcR) has been found on a small population of T cells. The immunological role of these T cells bearing the FcR (T y cells) remains to be established, but the possibility to be suppressor and/or killer has been suggested. In pathogenesis of atopic disorders, several authors reported the immunodeficiency state. The increase of serum IgE levels may be considered to be the result of low suppressor T cell activity for IgE production. Also, some immunodeficient state may relate to pathogenesis of acute glomerulonephritis (AGN) or nephrosis. In the present study, in order to investigate the immunological pathogenesis of bronchial asthma, AGN and nephrosis, T cells and T y cells in peripheral blood were counted and the ratio of T y cells to total T cells was estimated. Then, the significance of these cells in the diseases was discussed. T cells showed slight decrease in asthmatic children examined during attack. The ratio of T y cells showed no statistical correlation to serum IgE and IgG. In AGN, T y cells in‐creased and showed no change in nephrosis. Although the change of T and T y cells in bronchial asthma and AGN was revealed, the accurate role of these cells in the pathogenesis is probably complicated and still remains obscure. The change mentioned above may be the reflect of abnormal immune response which is associated with the pathogenesis of these diseases.