Premium
Colony Forming Capacity in Children with Normal Bone Marrow and Leukemia
Author(s) -
Nishihira Hirokazu,
Nakahata Tatsutoshi,
Akabane Taro
Publication year - 1975
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1975.tb02441.x
Subject(s) - bone marrow , medicine , acute leukemia , leukemia , colony forming unit , pathology , immunology , biology , genetics , bacteria
Summary The in vitro colony formation in 27 children with normal bone marrow and 37 children with acute leukemia (25 cases at onset or relapse and 12 cases during complete remission) has been studied. The number of colonies per 2 × 10 5 cells in children with normal bone marrow ranged from 110 to 504 and the average count was 248 colonies. This was a higher number of colonies than that reported in adult bone marrow. The colonies were about 65% compact colonies and about 35% loose colonies. In 19 cases of acute leukemia with the blasts in excess of 95% at onset or relapse, there was generally a decrease in colony forming capacity. One case of ALL showed an almost normal colony forming capacity. All of the 6 cases with the blasts of 30 to 60% developed colonies, but the number of colonies was less than that of normal bone marrow. Colony forming capacity in 12 cases with remission was similar to normal bone marrow. From the results, it is considered that in general colony formation in acute leukemia may be related to the ratio of blasts found in the bone marrow; however, in some cases of acute leukemia at onset or relapse there may be blasts that can differentiate and maturate.