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Enzymatic Development of the Human Fetus: The Isozymes of Glutamic Oxaloacetic Transaminase in Developing Human Fetal Tissues
Author(s) -
Mino Makoto,
Takai Toshio
Publication year - 1967
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1967.tb02138.x
Subject(s) - isozyme , fetus , medicine , transaminase , enzyme , physiology , enzyme assay , endocrinology , andrology , pregnancy , biochemistry , biology , genetics
Summary Studies on GOT and its isozyme during development of the human fetus were undertaken. Total GOT activity was found to show more striking increases after birth in the heart, liver as well as brain, than during the fetal life. In the heart, increased activity of total GOT after birth resulted from an increase in GOTm rather than from GOTs. In the liver, increase in total GOT activity during development resulted from an increase in the activity of both isozymes, but increases due to GOTm were more predominant. In the brain, increase in activity of both GOTm and GOTs were found to be similar, especially during development after birth. Low activity of GOT during fetal life was found to be attributable to a lack of the protein portion of the transaminase.