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Cystic Fibrosis Cases Found by Re‐examination of Histology of Pancreas and Postmortem Protocol in Japanese Children and Sweet Test on the Siblings
Author(s) -
Ikai Kimio,
Sugie Isamu,
Sugino Itsuro,
Nitta Hatsuo,
Iida Toshiko,
Ogawa Jiro,
Suchi Taizan
Publication year - 1965
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1965.tb01170.x
Subject(s) - cystic fibrosis , medicine , autopsy , sweat test , histology , pancreas , fibrosis , pathology , pancreatic disease , gastroenterology
Histology of the pancreas from about four hundreds autopsy cases at the Nagoya City University Hospital were re‐examined to single out cases of cystic fibrosis. The cases singled out concerning the pancreas received re‐examination of histology of other mucous gland that were available. Autopsy records and clinical histories were pursued and checked in detail. Pancreas and tracheobronchial glands in some cases were found to present histological pictures consistant with or suggestive of cystic fibrosis. This study suggests that there would be not a few cases of cystic fibrosis in Japan even if they are of a milder and incomplete form. Sweat test performed on the siblings of patients above singled out showed rather high value in some cases. A mean value in ten siblings were Na: 46.3 mEq/l, Cl: 41.0 mEq/l, and K: 4.9 mEq/l. It was believed that cystic fibrosis did not exist in the Mongolian until 1961 when two case reports appeared in the Acta Paediatrica Japonica. Since the Japanese is a mixed race of the pure Mongolian and the Ainu (the Caucasian remnant of once populous people in Japan), it is reasonable to assume there are many more cases of cystic fibrosis in Japan even if they are of a milder and incomplete form. In view of the disease's widespread significance and underlying implications of multiple associate diseases, and also from the antholopological interest, this study was planned as a part of a full scale investigation to single out cystic fibrosis among the general Japanese population. The present study involves re‐examination of histology of the pancreas from about four hundreds autopsy cases at the Nagoya City University Hospital. The cases which were singled out concerning the pancreas, received reexamination of histology of other mucous glands that were available. Autopsy records and clinical histories were pursued and checked in detail.