Open AccessANTAGONISM OF CHLORPHENAMIDINE TOXICITY TO THE CATTLE TICK BOOPHILUS MICROPLUS BY PIPERONYL BUTOXIDE
Author(s) -
Knowles Charles O.,
Roulston William J.
Publication year - 1972
Publication title -
australian journal of entomology
Language(s) - English
Resource type - Journals
eISSN - 1440-6055
pISSN - 1326-6756
DOI - 10.1111/j.1440-6055.1972.tb01640.x
Subject(s) - piperonyl butoxide , acaricide , tick , biology , toxicity , larva , metabolite , toxicology , antagonism , pesticide , biochemistry , botany , chemistry , ecology , organic chemistry , receptor
Piperonyl butoxide, a methylenedioxyphenyl type insecticidal synergist, antagonized the toxicity of the acaricide N ‐(4‐chloro‐2‐methylphenyl)‐ N′, N′ ‐dimethylformamidine to larvae of the cattle tick, Boophilus microplus. The toxicity of N ‐(4‐chloro‐2‐methylphenyl)‐ N′ ‐methylformamidine, a chlorphenamidine metabolite formed by oxidative N ‐demethylation, was not antagonized by this compound. It was concluded that piperonyl butoxide blocked the conversion of chlorphenamidine to demethylchlorphenamidine and that this “metabolic activation” reaction was a prerequisite for the killing action of chlorphenamidine in cattle tick larvae.