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Study of gastro‐oesophageal reflux disease in patients with mild‐to‐moderate chronic obstructive pulmonary disease in India
Author(s) -
KAMBLE NITISH L.,
KHAN NAUSHAD A.,
KUMAR NARESH,
NAYAK HEMANTA K.,
DAGA MRADUL K.
Publication year - 2013
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2012.02285.x
Subject(s) - medicine , reflux , asymptomatic , gastroenterology , copd , spirometry , gastro , incidence (geometry) , disease , pathological , asthma , physics , optics
Background and objective: To study the incidence and pattern of gastro‐oesophageal reflux disease (GORD) in patients with mild‐to‐moderate chronic obstructive pulmonary disease (COPD) using dual‐probe 24‐h oesophageal pH recording. Methods: This was a prospective study of 50 patients with mild‐to‐moderate stage COPD based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. A detailed history of illness along with spirometry was done in all patients. In the study group, reflux symptoms were measured using a validated scoring system. All the patients underwent oesophageal manometry and dual‐probe 24‐h oesophageal pH recording. Results: Symptoms of gastro‐oesophageal reflux were present in 38 patients. Twenty‐four‐hour oesophageal pH monitoring revealed pathological reflux in 31 out of 38 symptomatic and 8 out of 12 asymptomatic patients. The overall rate of GORD was 78% in our study. Only distal GORD was observed in 11 (28.9%), and both distal and proximal GORD was observed in 20 (52.6%) out of the 38 symptomatic subjects. In the remaining 12 asymptomatic patients, eight had GORD. Distal GORD was present in six (50%) patients, and two (16.6%) had both distal and proximal GORD in this group. Isolated proximal GORD was not observed in any patient. Conclusions: There is an increased occurrence of GORD in patients with even mild‐to‐moderate COPD.