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Invasive pulmonary aspergillosis in non‐neutropenic patients with and without underlying disease: A single‐centre retrospective analysis of 52 subjects
Author(s) -
DAI ZHICHU,
ZHAO HAIJIN,
CAI SHAOXI,
LV YANHUA,
TONG WANCHENG
Publication year - 2013
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2012.02283.x
Subject(s) - medicine , neutropenia , retrospective cohort study , mortality rate , aspergillosis , disease , significant difference , multivariate analysis , hazard ratio , surgery , chemotherapy , immunology , confidence interval
Background and objective: Invasive pulmonary aspergillosis (IPA) remains a life‐threatening infection in patients with prolonged neutropenia. Few data are available on IPA in non‐neutropenic patients without underlying immunocompromising conditions. Methods: All non‐neutropenic patients managed at the institution for a proven and probable IPA over the last 10 years were reviewed retrospectively, and the difference between non‐neutropenic patients with and without underlying disease was investigated. Results: Among 52 cases of IPA analysed here, 33 were histologically proven; 19 were probable. Forty‐two (80.8%) patients had underlying diseases; 10 (19.2%) patients had no any underlying diseases. There is a significant difference in seasonal distribution among patients with underlying conditions ( P = 0.026), but no seasonal difference was found in the other group ( P = 0.622). The only significant difference in symptoms between the two groups was fever ( P = 0.015). Radiological findings were non‐specific in the two groups. Despite treatment, the overall crude mortality rate among 52 patients was 39%. The overall mortality rate in patients with underlying disease was 45%, while that in patients without underlying conditions was 11%. A Cox multivariate analysis showed that organ failure (hazard ratios: 8.739, 95% CI: 3.770–20.255; P = 0.000) was independently associated with overall mortality. Conclusions: Clinical features of IPA are not well known in non‐neutropenic patients, especially in those without underlying conditions. In this study, organ failure was associated with a lower rate of survival of non‐neutropenic patients with IPA.